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KMID : 1130320120550090394
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Korean Journal of Pediatrics
2012 Volume.55 No. 9 p.394 ~ p.399
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Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity
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Lee Ji-Eun
Yoon Ju-Young
Lee Jin-A
Lee Seong-Yong
Shin Choong-Ho
Yang Sei-Won
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Abstract
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Purpose: Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism.
Methods: A total of 79 girls (6.3 to 12.4 years) were included in this study, of whom 34 were obese; 15, overweight; and 30, normal-weight. We examined their pubertal status and bone age. Fasting serum levels of total ghrelin, leptin, insulin, and first morning urinary 6-OHMS were measured. Homeostatic model assessment-insulin resistance (HOMAIR) was calculated from the fasting insulin and glucose levels.
Results: There was no significant difference in the creatinine adjusted 6-OHMS levels between the obese girls and the control group. Urinary 6-OHMS did not show any correlations with body mass index (BMI), BMI percentile, total ghrelin, leptin, and HOMA-IR. Negative correlations were found between urinary 6-OHMS levels and chronological and bone ages.
Conclusion: Our results suggest that melatonin production is not reduced consistently in obese girls.
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KEYWORD
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Obesity, Melatonin, 6-Sulfatoxymelatonin, Child
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